Smits Lab: reconstruction of gene regulatory network of the Gram Positive Pathogenic Bacterium Clostridium difficile

The Smits lab focuses on the reconstruction of gene regulatory network of the Gram positive pathogenic bacterium Clostridium difficile and the identification and characterization of potential targets for antibiotic development, especially DNA replication. We aim to understand how the integrity of the genome is maintained under environmental stresses, including those imposed by the host and by antimicrobials. The research employers a variety of genetic, molecular and biochemical techniques, which in part are developed within the group itself.

http://www.lumc.nl/smits