Lamers Lab: Mechanisms of high fidelity DNA replication

The Lamers lab studies the molecular mechanisms that ensure faithful replication of the genetic information stored in the DNA. In particular we are interested in how mutations are avoided during DNA synthesis, and errors removed after DNA synthesis. For this we study three intricately linked processes: DNA replication, DNA mismatch repair, and translesion DNA synthesis.
To gain insights into these complicated molecular processes, we use a combination of structural methods (cryo-EM, protein crystallography), biochemical methods, and single molecule methods. Together, these methods give a complete picture of high fidelity genome replication and provide new avenues to prevent increased mutagenesis that causes cancer in humans and antibiotic resistance in bacteria.