Dame Lab: Chromosome Structure and Function in Bacteria and Archaea

The Dame lab investigates the mechanisms by which the genomes of bacteria and archaea are structurally and functionally organized. The lab explores at the structural level how individual chromatin proteins act upon genomic DNA, how this translates into global organization of the genome inside life cells and how genome organization affects DNA transactions and vice versa. Of specific interest is how these processes are influenced by the cellular environment. The approach used combines molecular and cellular biochemistry with life cell imaging.