Selected Publications of CMCB Labs

Briegel Claessen Dame Lamers Smits  van Wezel

Briegel Lab

Yang, W., Alvarado, A., Glatter, T., Ringgaard, S., and Briegel, A. (2018) Baseplate variability of Vibrio choleraechemoreceptor arrays, Proceedings of the National Academy of Sciences of the United States of America 115, 13365-13370.

Briegel, A., Ortega, D. R., Mann, P., Kjaer, A., Ringgaard, S., and Jensen, G. J. (2016) Chemotaxis cluster 1 proteins form cytoplasmic arrays in Vibrio choleraeand are stabilized by a double signaling domain receptor DosM, Proceedings of the National Academy of Sciences of the United States of America 113, 10412-10417.

Briegel, A., Ortega, D. R., Huang, A., Oikonomou, C., Gunsalus, R. P., and Jensen, G. J. (2015) Structural conservation of chemotaxis machinery across Archaea and Bacteria, Environ Microbiol Reports 7, 414-419.

Briegel, A., Li, X. X., Bilwes, A. M., Hughes, K. T., Jensen, G. J., and Crane, B. R. (2012) Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins, Proceedings of the National Academy of Sciences of the United States of America 109, 3766-3771.

Briegel, A., Ortega, D. R., Tocheva, E. I., Wuichet, K., Li, Z., Chen, S. Y., Muller, A., Iancu, C. V., Murphy, G. E., Dobro, M. J., Zhulin, I. B., and Jensen, G. J. (2009) Universal architecture of bacterial chemoreceptor arrays, Proceedings of the National Academy of Sciences of the United States of America 106, 17181-17186.

Claessen Lab

Ramijan, K, E. Ultee, J. Willemse, Z. Zhang, J.A.J. Wondergem, A. van der Meij, D. Heinrich, A. Briegel, G.P. van Wezel & D. Claessen. (2018). Stress-induced formation of cell wall-deficient cells in filamentous actinomycetes. Nature Communications 9: 5164.

Zacchetti, B., J. Willemse, B. Recter, D. van Dissel, G.P. van Wezel, H.A.B. Wösten & D. Claessen. (2016). Aggregation of germlings is a major contributing factor towards mycelial heterogeneity of Streptomyces. Scientific Reports 6: 27045.

Petrus, M.L.C., E. Vijgenboom, A.K. Chaplin, J.A.R. Worrall, G.P. van Wezel & D. Claessen. (2016) The DyP-type peroxidase DtpA is a Tat-substrate required for GlxA maturation and morphogenesis in Streptomyces. Open Biology 6: 150149.

Claessen, D., D.E. Rozen, O.P. Kuipers, L. Søgaard-Andersen & G.P. van Wezel. (2014) Bacterial solutions to multicellularity: a tale of biofilms, filaments and fruiting bodies. Nature Reviews in Microbiology 12: 115-124.

Claessen, D., R. Rink, W. de Jong, J. Siebring, P. de Vreugd, F.G.H. Boersma, L. Dijkhuizen & H.A.B. Wösten. (2003) A novel class of secreted hydrophobic proteins is involved in aerial hyphae formation in Streptomyces coelicolorby forming amyloid-like fibrils. Genes and Development 17: 1714-1726.

Dame Lab

B. Henneman, C.L. van Emmerik, H. van Ingen & R.T. Dame. Structure and function of archaeal histonesPLOS Genetics. 14(9):e1007582. doi: 10.1371/journal.pgen.1007582, 2018.

R.A. van der Valk, J. Vreede, G.F. Moolenaar, A. Hofmann, N. Goosen & R.T. Dame. Environmentally driven conformational changes modulate the function of H-NSeLife.6:27369, 2017

R.P.C. Driessen, E. Peeters, F. Werner & R.T. DameThe interplay between nucleoid organization and transcription in archaeal genomesNature Reviews Microbiology. 13(6), 333-341, 2015.

N. Laurens, R.P.C. Driessen, I. Heller, D. Vorselen, M.C. Noom, F.J.H. Hol, M.F. White, R.T. Dame*& G.J.L. Wuite*. Alba shapes the archaeal genome using a delicate balance of bridging and stiffening the DNANature Communications. 3 (1328), 2012

R.T. Dame*, M.C. Noom & G.J.L. Wuite*Bacterial chromatin organization by H-NS protein unraveled using dual DNA manipulation. Nature444, 387-390, 2006.

Lamers lab

Zhao G, Gleave ES, Lamers MH. Single-molecule studies contrast ordered DNA replication with stochastic translesion synthesis. Elife. eLife Sciences Publications Limited; 2017 Dec 6;6:e32177. 

Baños-Mateos S, van Roon A-MM, Lang UF, Maslen SL, Skehel JM, Lamers MH. High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center. Nat Commun. Nature Publishing Group; 2017 Oct 11;8(1):855. 

Fernandez-Leiro R, Conrad J, Yang J-C, Freund SMV, Scheres SHW, Lamers MH. Self-correcting mismatches during high-fidelity DNA replication. Nat Struct Mol Biol. Nature Publishing Group; 2017 Feb;24(2):140–3. 

Rock JM, Lang UF, Chase MR, Ford CB, Gerrick ER, Gawande R, et al. DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader. Nat Genet. Nature Publishing Group; 2015 Jun;47(6):677–81. 

Fernandez-Leiro R, Conrad J, Scheres SH, Lamers MH. cryo-EM structures of the E. colireplicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and τ. Kowalczykowski SC, editor. Elife. eLife Sciences Publications Limited; 2015;4:459.

Smits Lab

Oliveira Paiva AM, Friggen AH, Qin L, Douwes R, Dame RT, Smits WK. The Bacterial Chromatin Protein HupA Can Remodel DNA and Associates with the Nucleoid in Clostridium difficile. J Mol Biol. 2019 Feb 15;431(4):653-672. doi: 10.1016/j.jmb.2019.01.001.

van Eijk E, Boekhoud IM, Kuijper EJ, Bos-Sanders IMJG, Wright G, Smits WK. Genome Location Dictates the Transcriptional Response to PolC Inhibition in Clostridium difficile. Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01363-18. doi: 10.1128/AAC.01363-18.

van Eijk E, Paschalis V, Green M, Friggen AH, Larson MA, Spriggs K, Briggs GS, Soultanas P, Smits WK. Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile. Open Biol. 2016 Dec;6(12). pii: 160272. doi: 10.1098/rsob.160272.

Smits WK, Lyras D, Lacy DB, Wilcox MH, Kuijper EJ. Clostridium difficile infection. Nat Rev Dis Primers. 2016 Apr 7;2:16020. doi: 10.1038/nrdp.2016.20.

van Eijk E, Anvar SY, Browne HP, Leung WY, Frank J, Schmitz AM, Roberts AP, Smits WK. Complete genome sequence of the Clostridium difficile laboratory strain 630Δerm reveals differences from strain 630, including translocation of the mobile element CTn5. BMC Genomics. 2015 Jan 31;16:31. doi: 10.1186/s12864-015-1252-7

van Wezel Lab

Wu, C., van der Heul, H.U., Melnik, A.V., Luebben, J., Dorrestein, P.C., Minnaard, A.J., Choi, Y.H., and van Wezel, G.P. (2019) Lugdunomycin, an angucycline-derived molecule with unprecedented chemical architecture. Angew Chem Int Ed Engl. https://doi.org/10.1002/anie.201814581

Dissel, D., Willemse, J., Zacchetti, B., Claessen, D., Pier, G.B., and van Wezel, G.P. (2018) Production of poly-beta-1,6-N-acetylglucosamine by MatAB is required for hyphal aggregation and hydrophilic surface adhesion by Streptomyces. Microb cell 5: 269-279.

Celler, K., Koning, R.I., Willemse, J., Koster, A.J., and van Wezel, G.P. (2016) Cross-membranes orchestrate compartmentalization and morphogenesis in Streptomyces. Nat Commun 7: 11836.

Barka, E.A., Vatsa, P., Sanchez, L., Gavaut-Vaillant, N., Jacquard, C., Meier-Kolthoff, J., Klenk, H.P., Clément, C., Oudouch, Y., and van Wezel, G.P. (2016) Taxonomy, physiology, and natural products of the Actinobacteria. Microbiol Mol Biol Rev 80: 1-43.

Willemse, J., Borst, J.W., de Waal, E., Bisseling, T., and van Wezel, G.P. (2011) Positive control of cell division: FtsZ is recruited by SsgB during sporulation of Streptomyces. Genes Dev 25: 89-99.